Protective role of autophagy in mouse cecal ligation and puncture-induced sepsis model
نویسندگان
چکیده
منابع مشابه
Kinetics and protective role of autophagy in a mouse cecal ligation and puncture-induced sepsis
INTRODUCTION It is not well understood whether the process of autophagy is accelerated or blocked in sepsis, and whether it is beneficial or harmful to the immune defense mechanism over a time course during sepsis. Our aim was to determine both the kinetics and the role of autophagy in sepsis. METHODS We examined autophagosome and autolysosome formation in a cecal ligation and puncture (CLP) ...
متن کاملA New Approach to Monitoring and Evaluation of Cecal Ligation and Puncture Sepsis Model
Background: Sepsis is a systemic inflammatory disease in response to the pathogens that leads to vital organ failures the failure of vital organs. Appropriate animal models should be developed to measure the effectiveness of therapeutic methods. Cecal Ligation and Puncture (CLP) is the most widely used methods of creating the sepsis model. Some variables interfere in the creation of the CLP mod...
متن کاملSuppression of T Cell Autophagy Results in Decreased Viability and Function of T Cells Through Accelerated Apoptosis in a Murine Sepsis Model*
OBJECTIVE While type 1 programmed cell death (apoptosis) of T cells leads to immunosuppression in sepsis, a crosstalk between apoptosis and autophagy (type 2 programmed cell death) has not been shown. The aim of this study is to elucidate the details of the interaction between autophagy and immunosuppression. DESIGN Laboratory investigation in the murine sepsis model. SETTING University lab...
متن کاملEvaluation of the brain tissue oxidative stress status during sepsis after mesenchymal stem cell\'s conditioned medium administration in male rats
Background: In the present study, we hypothesized that conditioned medium (CM) derived from mesenchymal stem cells attenuates the brain oxidative stress in sepsis induced by the cecal ligation and puncture (CLP) model. Methods: This study was performed in the Department of Physiology at Tehran University of Medical Sciences from August 2018 to April 2019. Conditioned medium was collected from ...
متن کاملتاثیر اسانس زیره سیاه بر سطح فاکتورهای استرس اکسیداتیو در بافتهای قلب و کلیه رتهای سپتیکی
Abstract Background: Sepsis is a systemic response to severe infections leading to organ failure and death. Recently the role of herbal drugs in the management of the inflammatory response has come under increased scrutiny. Caraway is a well known traditional herbal plant believed to contain active components with pharmacological properties such as antioxidative effects. In this study attemp...
متن کامل